Human dorsal root ganglion neurons from embryonic donors extend axons into the host rat spinal cord along laminin-rich peripheral surroundings of the dorsal root transitional zone.
Kozlova EN; Seiger A; Aldskogius H, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow. J Neurocytol, 1997 Dec, 26:12, 811-22
Following dorsal root crush, the lesioned axons regenerate in the peripheral compartment of the dorsal root, but stop at the boundary between the peripheral and the central nervous system, the dorsal root transitional zone. We have previously shown that fibres from human fetal dorsal root ganglia grafted to adult rat hosts are able to grow into the spinal cord, but were not able to specify.
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